Guggulsterones stimulate the thyroid gland, which in turn produces more thyroid hormones; such as thyroxin. These thyroid hormones have a profound effect on the

rate of metabolism, including a direct catabolic effect on adipose tissue. Practically,

this means that Guggulsterones will stimulate the thyroid to produce more

thyroid hormones, which in turn will raise metabolism and burn more fat.

Guggulsterones increase the peripheral conversion of T4 into T3. Increasing the peripheral conversion of T3 is highly important because the thyroid only produces

20% of the body's T3. Most of the remaining 80% is derived from T4 through a conversion process that occurs in various target tissues, such as skeletal muscle

for example.